解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.112516
更新日期:2010-04-01 00:00:00
abstract::BTB-zinc finger transcription factors play many important roles in metazoan development. In these proteins, the BTB domain is critical for dimerization and for recruiting cofactors to target genes. Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. He...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.111591
更新日期:2010-04-01 00:00:00
abstract::We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.113183
更新日期:2010-03-01 00:00:00
abstract::In many organisms, female and male meiosis display extensive sexual dimorphism in the temporal meiotic program, the number and location of recombination events, sex chromosome segregation, and checkpoint function. We show here that both meiotic prophase timing and germ-line apoptosis, one output of checkpoint signalin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.110338
更新日期:2010-03-01 00:00:00
abstract::TAHRE, the least abundant of the three retrotransposons forming telomeres in Drosophila melanogaster, has high sequence similarity to the gag gene and untranslated regions of HeT-A, the most abundant telomere-specific retrotransposon. Despite TAHRE's apparent evolutionary relationship to HeT-A, we find TAHRE Gag canno...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.109744
更新日期:2010-03-01 00:00:00
abstract::Though much has been learned about the process of ovarian follicle maturation through studies of oogenesis in both vertebrate and invertebrate systems, less is known about how follicles form initially. In Drosophila, two somatic follicle stem cells (FSCs) in each ovariole give rise to all polar cells, stalk cells, and...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.109538
更新日期:2010-02-01 00:00:00
abstract::Active endogenous transposable elements, useful tools for gene isolation, have not been reported from any legume species. An active transposable element was suggested to reside in the W4 locus that governs flower color in soybean. Through biochemical and molecular analyses of several revertants of the w4-m allele, we ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.107904
更新日期:2010-01-01 00:00:00
abstract::An analysis of mortality is undertaken in two breeds of pigs: Danish Landrace and Yorkshire. Zero-inflated and standard versions of hierarchical Poisson, binomial, and negative binomial Bayesian models were fitted using Markov chain Monte Carlo (MCMC). The objectives of the study were to investigate whether there is s...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.110759
更新日期:2010-01-01 00:00:00
abstract::The Saccharomyces cerevisiae SEN1 gene codes for a nuclear-localized superfamily I helicase. SEN1 is an ortholog of human SETX (senataxin), which has been implicated in the neurological disorders ataxia-ocular apraxia type 2 and juvenile amyotrophic lateral sclerosis. Pleiotropic phenotypes conferred by sen1 mutations...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.110031
更新日期:2010-01-01 00:00:00
abstract::The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which make N. furzeri a uniqu...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.108670
更新日期:2009-12-01 00:00:00
abstract::We consider a population that adapts to a gradually changing environment. Our aim is to describe how ecological and genetic factors combine to determine the genetic basis of adaptation. Specifically, we consider the evolution of a polygenic trait that is under stabilizing selection with a moving optimum. The ecologica...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106195
更新日期:2009-12-01 00:00:00
abstract::The race-specific resistance gene Pi-ta has been effectively used to control blast disease, one of the most destructive plant diseases worldwide. A single amino acid change at the 918 position of the Pi-ta protein was known to determine resistance specificity. To understand the evolutionary dynamics present, we examin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.108266
更新日期:2009-12-01 00:00:00
abstract::Much recent work in the theoretical study of adaptation has focused on the so-called strong selection-weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution. Here we extend this t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106757
更新日期:2009-11-01 00:00:00
abstract::Magnesium (Mg) is an essential enzyme cofactor and a key structural component of biological molecules, but relatively little is known about the molecular components required for Mg homeostasis in eukaryotic cells. The yeast genome encodes four characterized members of the CorA Mg transporter superfamily located in the...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106419
更新日期:2009-11-01 00:00:00
abstract::In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some proteins in daughter ce...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106492
更新日期:2009-10-01 00:00:00
abstract::The point mutation rate of phage PhiX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0x10(-6) substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per roun...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106005
更新日期:2009-10-01 00:00:00
abstract::We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretation...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.103853
更新日期:2009-09-01 00:00:00
abstract::Neutrality tests based on the frequency spectrum (e.g., Tajima's D or Fu and Li's F) are commonly used by population geneticists as routine tests to assess the goodness-of-fit of the standard neutral model on their data sets. Here, I show that these neutrality tests are specific instances of a general model that encom...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.104042
更新日期:2009-09-01 00:00:00
abstract::Chromatin insulators separate active from repressed chromatin domains. In yeast the RNA pol III transcription machinery bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict the spread of heterochromatin. Our results collectively demonstrate that binding of TFIIIC is necessary for i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106203
更新日期:2009-09-01 00:00:00
abstract::Naturally transformable bacteria acquire chromosomal DNA from related species at lower frequencies than from cognate DNA sources. To determine how genome location affects heterogamic transformation in bacteria, we inserted an nptI marker into random chromosome locations in 19 different strains of the Acinetobacter gen...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.103127
更新日期:2009-08-01 00:00:00
abstract::DNA sequence analysis and genetic mapping of loci from mating-type-specific chromosomes of the smut fungus Microbotryum violaceum demonstrated that the nonrecombining mating-type-specific region in this species comprises approximately 25% ( approximately 1 Mb) of the chromosome length. Divergence between homologous ma...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.103192
更新日期:2009-08-01 00:00:00
abstract::Centric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.105338
更新日期:2009-08-01 00:00:00
abstract::Using zinc-finger nucleases (ZFNs) to cleave the chromosomal target, we have achieved high frequencies of gene targeting in the Drosophila germline. Both local mutagenesis through nonhomologous end joining (NHEJ) and gene replacement via homologous recombination (HR) are stimulated by target cleavage. In this study we...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101329
更新日期:2009-07-01 00:00:00
abstract::The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1 regulates Adr1 is unkno...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.103432
更新日期:2009-07-01 00:00:00
abstract::The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C(2)H(2)'s and a C(2)HC motif that a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101667
更新日期:2009-07-01 00:00:00
abstract::To gain new mechanistic insight into ER homeostasis and the biogenesis of secretory proteins, we screened a genomewide collection of yeast mutants for defective intracellular retention of the ER chaperone, Kar2p. We identified 87 Kar2p-secreting strains, including a number of known components in secretory protein modi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101105
更新日期:2009-07-01 00:00:00
abstract::Genomic integrity is threatened by multiple sources of DNA damage. DNA double-strand breaks (DSBs) are among the most dangerous types of DNA lesions and can be generated by endogenous or exogenous agents, but they can arise also during DNA replication. Sister chromatid recombination (SCR) is a key mechanism for the re...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101899
更新日期:2009-06-01 00:00:00
abstract::Stress-induced mutagenesis is a collection of mechanisms observed in bacterial, yeast, and human cells in which adverse conditions provoke mutagenesis, often under the control of stress responses. Control of mutagenesis by stress responses may accelerate evolution specifically when cells are maladapted to their enviro...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.100735
更新日期:2009-05-01 00:00:00
abstract::The availability of genomewide dense markers brings opportunities and challenges to breeding programs. An important question concerns the ways in which dense markers and pedigrees, together with phenotypic records, should be used to arrive at predictions of genetic values for complex traits. If a large number of marke...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101501
更新日期:2009-05-01 00:00:00
abstract::We propose a novel approximate-likelihood method to fit demographic models to human genomewide single-nucleotide polymorphism (SNP) data. We divide the genome into windows of constant genetic map width and then tabulate the number of distinct haplotypes and the frequency of the most common haplotype for each window. W...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.099275
更新日期:2009-05-01 00:00:00
abstract::Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p. These four proteins all participate in or influence a well-studied agglutinin interaction mediated by Aga1p-Aga2p complexes and Sag1p; however, they also play redundant and essent...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.100073
更新日期:2009-05-01 00:00:00
abstract::Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.094607
更新日期:2009-04-01 00:00:00
abstract::This work demonstrates that environmental conditions experienced by individuals can shape their development and affect the stability of genetic associations. The implication of this observation is that the environmental response may influence the evolution of traits in the wild. Here, we examined how the genetic archi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.086801
更新日期:2009-04-01 00:00:00
abstract::Functional analyses of the Arabidopsis genome require analysis of the gametophytic generation, since approximately 10% of the genes are expressed in the male gametophyte and approximately 9% in the female gametophyte. Here we describe the genetic and molecular characterization of 67 Ds insertion lines that show reduce...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.090852
更新日期:2009-04-01 00:00:00
abstract::The uaY gene encodes the transcriptional activator of purine catabolism genes in Aspergillus nidulans. uaY12 results in strongly defective growth on purines as nitrogen sources and in strongly diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generati...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.099515
更新日期:2009-04-01 00:00:00
abstract::Insulin-like growth factors (IGFs) control cell and organism growth through evolutionarily conserved signaling pathways. The mammalian acid-labile subunit (ALS) is a secreted protein that complexes with IGFs to modulate their activity. Recent work has shown that a Drosophila homolog of ALS, dALS, can also complex with...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.099531
更新日期:2009-04-01 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are an important family of signaling molecules with the unusual property that they are able to transduce their signals using the same downstream pathways. This has led to an unresolved debate as to whether individual receptors are interchangeable, or if each receptor can mediate specif...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.098475
更新日期:2009-04-01 00:00:00
abstract::Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. Ubiquitin E3 ligases confer substrate specificity in this pathway, and SCF-type ligases comprise a major class of E3s. SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate rec...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.097675
更新日期:2009-03-01 00:00:00
abstract::As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.099929
更新日期:2009-03-01 00:00:00
abstract::Cell-cell fusion is essential for a variety of developmental steps in many eukaryotic organisms, during both fertilization and vegetative cell growth. Although the molecular mechanisms associated with intracellular membrane fusion are well characterized, the molecular mechanisms of plasma membrane merger between cells...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.096149
更新日期:2009-02-01 00:00:00